Endocrine Abstracts

We are living in the electronic era and day to day exposed by estrogenic disruptors such as Bisphenol-A (BPA). Electronic gadgets such as cellular phones, CDs, DVDs, RFIDs even baby feeding bottles are made with composition of BPA and their huge application are matter of debate in present. The chronic exposures of BPA have become a major health concern. In this study we assessed the neurobehavioral alterations caused by BPA in the rats. We examined the neurobehavioral changes ...

Introduction: The most prevalent hereditary disease of adrenal steroid production is congenital adrenal hyperplasia (CAH), which is caused by a 21-hydroxylase deficiency. With or without salt wasting, patients with the typical form of CAH exhibit androgen excess. Leptin participates in endocrine and metabolic processes in addition to controlling energy balance. This study examined BMI values for children and teens with CAH in comparison to population-based benchmarks. Current ...

Introduction: Diabetic foot ulcers (DFU) have developed into a more common complication among people with uncontrolled diabetes, who also have higher morbidity rates and are more prone to polymicrobial infections that spread quickly and cause irreparable tissue damage. The most difficult aspect of treating diabetic foot ulcers (DFU) is the rising prevalence of multi-drug resistant germs, which necessitates the use of a novel antimicrobial agent.Objective...

Background: Glycated albumin (GA) and glycated haemoglobin (HbA1c) measurements have been used to track the long-term glycemic management of diabetic patients. Other than glycemia, there are known influences on both glycated proteins. In obese, non-diabetic children, GA levels have been found to be low, while in adult diabetic patients, GA levels have been found to be adversely correlated with body mass index (BMI). The causes of the link between obesity and GA are still unkno...

Background: Obesity is the major health problem in both developed and developing countries, due to increasing its rate there is a new strategy to prevent obesity by time restricted feeding (TRF). The aim of our study is the effect of TRF intervention on diet induced obese rats and their association with circadian gene expression.Method: Total 15 Wistar rats were included in our study and divided into two groups. Control group and High Fat diet (HFD) grou...

Introduction: It is unknown what causes ageing men to have lower testosterone levels and how those levels relate to risk factors. Less research has been done on the health of ageing males than on postmenopausal women.Objective: The aim was to look into how men-aging lifestyles and health related to their levels of reproductive hormones.Method: A prospective cohort study in Indian men included 320 community-dwelling men between the ...

Introduction: Numerous thyroid function disturbances have been linked to the administration of growth hormone (GH) to GH-deficient patients. There have been reports of anything from increased energy expenditure and improved peripheral thyroxine (T4) to triiodothyronine (T3) conversion to decreased thyrotropin (TSH) sensitivity to thyrotropin-releasing hormone (TRH) stimulation and induction of hypothyroidism.Objective: GH has an impact on thyroid structu...

Introduction: An autosomal recessive illness called the syndrome of familial GH-resistant short stature is characterized by a phenotype that is similar to that of isolated GH deficiency, but with normal or excessive GH production and decreased IGF-I synthesis. When these individuals are treated with GH, neither growth nor a rise in blood somatomedin/IGF-I activity—the mediator of GH’s growth-promoting effects—are stimulated. This suggests that the cause of the g...

This study aimed to determine if berberine (BBR) or pioglitazone (PGZ) is more effective and safer for treating people with type 2 diabetes or non-alcoholic fatty liver disease (NAFLD). 184 people with NAFLD and impaired glucose metabolism were randomly allocated 16 weeks of lifestyle intervention (LI), LI plus PGZ (15mg daily) or LI plus BBR (1.5 g daily) as their course of treatment. We measured the levels of blood insulin, osteocalcin, C reactive protein (CRP), liver enzyme...

A 65 yo gentleman was referred to the endocrinology department with thyrotoxicosis. He had a history of IHD and recurrent VT necessitating amiodarone for 8 years. Routine TFTs had shown TSH undetectable, fT4 34.1, fT3 8.7. There were no symptoms or signs of thyrotoxicosis or cardiovascular compromise. He had been treated with carbimazole by his GP for the previous 3 weeks, this was discontinued at the initial evaluation due to recurrent vomiting. TPO anti...